The Longevity Formula
Is there a secret formula to living a longer, healthier life?
The Longevity Formula offers a comprehensive approach to well-being, providing actionable insights and strategies to transform your life and achieve holistic health and longevity.
This formula encompassing faith, light, movement, mindset, nutrition, and science, serves as your roadmap towards your best self. This podcast is designed for those who are driven to optimize their lives through the dynamic fusion of science, technology, and lifestyle choices.
As a leading functional neurologist, Dr. Brandon Crawford shares his expertise in brain healing and optimization. With a proven track record of restoring functions lost to brain injuries and tackling complex neurological disorders, Dr. Crawford reveals the profound potential within us all.
Unlock your brain's potential and discover the secrets to a long and healthy life. Tune in every Friday for a new episode.
The Longevity Formula
The Foundational Molecule: Dr. Nathan Bryan on Why Nitric Oxide Changes Everything
The episode features an urgent conversation with renowned nitric oxide biochemist Dr. Nathan Bryan, who explains why nitric oxide is the foundational molecule of health, connecting everything from cardiovascular function to Alzheimer's prevention.
Dr. Bryan details how nitric oxide regulates blood flow, mobilizes stem cells, and controls mitochondrial energy production. He argues that the loss of nitric oxide production, often caused by the destruction of the oral microbiome (via antiseptic mouthwash and fluoride) and poor light environments, is the root cause of many chronic diseases. He explains his scientific approach to restoring nitric oxide with a patented lozenge, affirming his mission to develop therapeutic solutions that help patients get off prescription drugs, despite significant pushback.
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Voice Over: Welcome to the Longevity Formula with Dr. Brandon Crawford. Let's explore the new era of wellness.
Dr. Brandon Crawford: Hey everyone, we are recording this just months after one of the most viral health. Podcast of 2025. Dr. Nathan Brian's explosive appearance on the diary of a CEO where he claimed the cure for Alzheimer's already exists.
That episode has been viewed millions of times, in fact, checked across. The internet. Meanwhile, we're living through the Make America Healthy again, movement with RFK Junior, promising to end chronic disease through government policy. But what if the real solution is not political? What if it's molecular?
Today's guest is Dr. Nathan Bryan, the nitric oxide biochemist, whose research just might hold the key to actually making America healthy again. Not through bureaucracy, but through biology. With over 100 peer reviewed publications and patents that have generated over a billion dollars in global sales, Nathan has spent 20 years uncovering why a simple gas molecule might be the missing link in our health.
Crisis. What makes this conversation so timely is that while politicians debate, food dies and vaccine schedules, Nathan's research suggests we're missing the fundamental biological mechanism that could prevent most chronic diseases before they start. Nathan, welcome to the Longevity Formula, Nathan. So let's start with the line that kind of broke the internet here recently.
You told Steven Bartlett that the cure for Alzheimer's already exists, right? So this garnered millions of views and dozens of fact checkers and all kinds of stuff, right? I loved it. I think it was fantastic. What'd you mean by that? And why'd you bring that up to Steven?
Dr. Nathan Bryan: Well, you know, I intentionally meant it to be provocative, but you know, it's, it's more than provocative because I think it's scientifically validated.
It corroborates what we see from understanding the basic mechanism of action or mechanism of what causes Alzheimer's and dementia. And then, you know, how do we develop rational therapies to address root cause of that.
Dr. Brandon Crawford: Absolutely.
Dr. Nathan Bryan: Yeah.
Dr. Brandon Crawford: Good. Well, so were you surprised by the amount of blowback or like what did that, what'd that do for you whenever you were on this, you know, super public podcast, like everyone's tuning in?
Like what kind of blowback did you get from that statement?
Dr. Nathan Bryan: You know, I really didn't get any blowback. I mean, I got a lot of questions, but I just send people the data and the science on what I meant by that.
Dr. Brandon Crawford: That's awesome. And you
Dr. Nathan Bryan: know, when, when there's, when there's data, real data, both basic science, clinical validation, epidemiological data that support what we're doing, and, and back up that statement, there's, there's no response other than you know, the, the data.
Or the data, right? And so absolutely how most of the comments were pretty you know, favorable and really giving people hope because. You know before that people with Alzheimer's and dementia have no hope. And hope is a very powerful force in people's lives. And so if nothing else, if we give people hope, you know, but I think we're gonna do better than that.
And I, I still stand by that statement as we've advanced these drugs through clinical trials, we're gonna show and we're gonna see that we can. Prevent, cure, reverse Alzheimer's.
Dr. Brandon Crawford: Yes, absolutely. I think that speaks a lot to the quality of your data and your stance on this topic. You know, whenever you can make such a bold statement but then back it up, that's huge.
So for people who don't really know exactly what we're talking about right now and who don't speak molecular biochemistry, can you walk us through what is. Nitric oxide. Why should we care so much about this molecule?
Dr. Nathan Bryan: Yeah. Well, no, it's, it's a naturally produced gas in the human body. It's what we call a signaling molecule.
Nobel Prize was awarded for its discovery in 1998 for the discovery as a signaling molecule in the cardiovascular system. So this molecule, this gas is naturally produced. It regulates blood flow. We published in 2011 that it, it's, it's the signal that. You know, controls insulin sensitivity and insulin signaling and glucose subrate.
It mobilizes our own stem cells. So if you make nitric oxide, you have a, a larger number of stem cells in circulation. It prevents oxidative stress. It, it it inhibits inflammation. It corrects the immune dysfunction that we see in chronic disease. So everything we know about health, longevity, disease prevention is dependent upon the body's ability to produce nitric oxide.
That's huge.
Dr. Brandon Crawford: So how come providers? Okay, so there was a Nobel Prize Award in 1998.
Dr. Nathan Bryan: Yeah.
Dr. Brandon Crawford: What you just told me and, and is all true. Right? This one molecule is connected to so many different aspects of health, healing, and longevity. I mean, you even talked about stem cells, right? So the ability to to truly heal and repair systems is so intimately connected with this molecule of nitric oxide.
I guess one question is why are providers not really engaging in this conversation about nitric oxide health and how this can impact their patients? But then number two, how do they,
Dr. Nathan Bryan: well, the, the, to answer, the first question is physician in medicine today, you know, physicians treat what they can measure, right?
Mm-hmm. They treat labs, they treat numbers. And right or wrong. That's just how it is. And that's, I think that's why western medicine is, is so ineffective at making people better. Nitric oxide is not something that we can measure in a clinical setting. I mean, we can, but it's not done. So it's, it's not like if you go to your physician and you get your triglycerides or your vitamin D or a cholesterol, then we can treat that number.
There is no measurement for nitric oxide because nitric oxide iss a gas. It's produced. Once it's produced, it's gone in less than a second. So if you can't measure it, you know, physicians think, most physicians think if you, if you can't measure it, then it's not important. The only thing that's important is what you can measure and what you can track.
And that's partly true, but some of the most important things that we, that are regulating and modulating biochemistry and physiology, things we can't measure. So that's number one. And then number two. Is that we can measure nitric oxide, although it's not done clinically, we can, you know, I've developed some analytical techniques and salivary test strips.
I don't use 'em anymore, but there's functional medical devices that give us an indication of how well our blood vessels produce this gas, and we call that endothelial function or endothelial dysfunction. Our blood blood vessels can't make nitric oxide, so there are bonafide objective measures of nitric oxide production, endothelial function.
But most physicians don't utilize it. So if they can't measure it, they don't treat it
Dr. Brandon Crawford: right. So a, a practicing provider, let's say. Okay, so I'm dealing with neuroplasticity, so I'm looking at people with brain injuries or neurodevelopmental disorders, autism this kind of stuff. What type of clinical observations should I be making that are going to help connect the dots for me to know this person needs better regulation of their nitric oxide pathways?
Dr. Nathan Bryan: Well, in terms of urological disease, you can follow the work of Daniel Layman and do SPECT scans because spec scans really are a way to measure cerebral blood flow and how well parts of different regions of the brain are profused. And if you look at the data on spec scans, whether it's dementia, Alzheimer's, A DHD, addictive disorders, Parkinson's disease, the commonality in all those is there's a loss of regulation of blood flow.
So the spec scans will show holes in the brain. Mm-hmm. Or what we call focal ischemia. These are non-invasive imaging modalities. And you can, you can, you can demonstrate and illustrate to that patient. That, that that part of the brain is not getting adequate blood supply. And without oxygen, without nutrients, without glucose uptake into the brain cells, the, the cells don't work.
Right. And they manifest as different neurological diseases.
Dr. Brandon Crawford: Right. So another way that I'm looking at, right, so in functional neurology. This foundational work is based on the, the Nobel Prize of Dr. Adrian and Dr. Sherington back in 1932, who discovered the central integrated state of, of the brain of the neuron.
That central integrated state is thus dependent upon. Mitochondrial function and blood flow, right? And so absolutely if, if I can start to analyze someone through functional neurology, right? I can look at muscle imbalances, abnormal movements, reflexes, all of this kinda stuff, and I can find areas of the brain with this altered central integrated state.
I think it's just a natural correlation that there must be nitric oxide dysregulation in these areas as well. Therefore, I need to support it. Is that accurate?
Dr. Nathan Bryan: I think that's accurate because number one, it's a blood flow problem. You mentioned another important aspect of all chronic disease is mitochondrial dysfunction.
Mm-hmm. So if the mitochondria can't utilize oxygen to make the energy currency of the cell, which is a TP, then those cells don't have the energy to do their job and and perform their function. Interestingly, nitric oxide is what controls and regulates the efficiency of oxygen utilization to make cellular a TP.
Furthermore, if we make nitric oxide and induces mitochondrial biogenesis, and now we have more mitochondria per cell, generating more energy, more efficiently, even with less oxygen. So that's, that's an important aspect of getting to, again, not just molecular medicine, but you know, subcellular, organal, mitochondrial function and all that's regulated by nitric oxide.
So when we start to look at, and when we look at what are you looking for as a function, I think these functional tests are absolutely essential. But there are also risk factors or things that predispose people to certain diseases or, or, or symptoms. So when we look at kind of the hierarchy of nitric oxide deficiency symptoms, right?
So usually if, if a person becomes nitric oxide deficient in the general population, I'm not talking about people with you know, genetic disease or things like that. But typically the first sign and symptom is erectile dysfunction. We can't dilate the blood vessels of the sex organs because our body can't make nitric oxide.
Then we develop erectile dysfunction. Then your blood pressure starts to go up. Then you develop metabolic disease, insulin resistance, and then exercise intolerance. And then you start to see mild cognitive impairment dimension, eventually Alzheimer's. So those are things that physicians can look at both from, you know, hierarchy of symptoms, clinical manifestations, and then combined with functional measurements.
I think you, you start to get a clear clinical picture on that patient.
Dr. Brandon Crawford: Absolutely. I like to go just a little step further into the mitochondrial story, right? So I'm a big light guy. Yep. Obviously I've developed lasers and, and use light and laser therapy therapeutically all over the body, specifically in the brain.
Do you think that one's light environment actually has an impact on their nitric oxide health and ability to really regulate the, the IE and NN Os?
Dr. Nathan Bryan: No, without a doubt. I mean, this data is, again, this, this answer is supported by data looking at epidemiological data. People who live in the Northern hemisphere where there's less light per year, they have higher incidence of hypertension, Cecil affective disorder, mitochondrial dysfunction.
Then if you go all the way down from epidemiological to to cellular molecular medicine, biochemistry, we know that light affects nitric oxide production. So there's frequencies of light that can, so when nitric oxide ISS produced. It binds to metals and it can be bound to metals or it can modify cystine ths on proteins and be, you know, an SNO bond, this covalent bond and certain the kind of the infrared spectrum, that frequency of an energy can release nitric oxide bound to metals.
So it's liberating what we call photo lab stores of nitric oxide. And then on the other end of the spectrum, ultraviolet light. Is, is a high enough energy to where it can release nitric oxide, bound to proteins and break that covalent bond. In fact, we use that in analytical chemistry a UV lamp to cleave, SNO bonds.
So we live in an environment where we're exposed to artificial light, right? And we've been programmed to avoid the sun because of skin cancer and put on, you know, toxic skin. You know, sunscreens. Mm-hmm. So we live in an environment where we're not exposed to natural light, and there's obvious health consequences to that.
So, to answer your question, light's extremely important. You know, it's, it's affecting mitochondrial production of, of energy. It's, it's liberating nitric oxide. So we can harness those as you've done therapeutically to, to make people better.
Dr. Brandon Crawford: Absolutely. And just to kind of. You know, reiterate what you were saying.
There was a study, I believe it was in 2014, where they showed just 20 minutes of sunlight per day reduced blood pressure. Right. And their mechanism was defined as releasing dermal nitric oxide. Right. That was one of the mechanisms. And they showed that this happened actually without increasing vitamin D.
So they, they didn't want the correlation of, oh, it was just the, the rise of vitamin D. Right. So there, you're right, there's good data out there to support that proper light environments actually supports our nitric oxide pathways. Well, that obviously then means, okay, well then poor light environments would dysregulate this nitric oxide pathway, this whole nitric oxide story.
Right? And I, I wanna make it real clear to the audience, because I talk about this all the time, this is just a different perspective, right? You have to get your light right first and. There's other things to talk through. I want to talk through the oral microbiome and why that's so important and mouth breathing, breathing versus nose breathing, and all of those concepts.
But this is such a foundational concept for me and the reason, so my big reset, what I do at least once a week, usually multiple times a week. Is I'll go for about a four to five mile jog and it will be midday. I'll have no shirt on 'cause I want the sun exposure. Yep. Be one of the primary reasons I wanna do this, besides it just clears my head is getting the exercise.
So I'm really working on the ENOS right. Coupled with the sun exposure. So I'm actually getting that UVA exposure, releasing more nitric oxide from my skin, et cetera. So it's a huge. Reset of the nitric oxide pathways. It's, it's great on so many levels, but one of my primary ways I like to regulate for myself is exercise in the sun.
Do you agree with that strategy?
Dr. Nathan Bryan: Absolutely, and I, I, I just practice a similar strategy, but I do it first thing in the morning. Yes. I like to see the first, because I, if I wait till I have time in the day to work out, it never gets done except to make time. And that time for me is first thing in the morning.
So I wake up and when the sun comes up, I'm out there and typically, you know, I live out in the country. I don't have neighbors, but I'm out naked. I'm fully exposed to the sun. I'm doing exercises. I've just got outta my infrared sauna. I start my day every day with a 30 minute infrared sauna. So I'm exposed to, to red light detoxing.
Then I'll typically do a cold plunge, and then I work out outside barefoot, touching the ground, watching the sun come up. To me, that's just a complete reset. It resets my circadian rhythm, gets my day started. You know, blood flow going and it's. Know, since I've done that, it's, it's, it's changed the way that it's changed my life.
Dr. Brandon Crawford: Absolutely. So next time I'll run naked through my community instead, but no, I I actually do the same. Right. So I, I'm out in the country. I, I absolutely will lay by the pool. We'll do everything with as little clothing or No clothing as possible. For sure. And you're right. One thing to touch on is. That light, that early morning sunrise at low angle sunlight is vitally important to help really reset those circadian cycles.
That is the purest form of red light you can ever you can ever come in contact with. So you're absolutely right. I have a weird way I love running in the intense heat. It is one way where I do it to generate heat pro heat shock proteins I run until I start to see spots. I, so it is, it is kind of a dopamine thing for me as well to, to run during this time of day.
So that's a whole nother another story. And you know, maybe that's just you know, me kinda being weird, but whatever. So if you don't mind, let's kind of talk about this concept of. Oral health. Why does this matter? When we're talking about the brain and the heart and the, all these things that nitric oxide touches our entire cascade of, of nitric oxide, does it really start in the mouth?
Dr. Nathan Bryan: Yeah. Look, it's more than that. Disease starts in the mouth. And when I, when, you know, when I, we started publishing on this almost 15, 20 years ago, trying to identify dysbiosis in the mouth and seeing this observation that if you eradicated the oral bacteria, blood pressure went up. And then we started identifying these bacteria that were responsible for producing nitric oxide in the human body.
And so I go, well, why are, you know, you see the commercials on tv, this, this mouthwash kills 99.99% of the bacteria in your mouth. These companies are proud of this and they advertise this. And to me it's just a complete ignorance of the science or complete you know, ignoring the science. Because when I think back, why did all this start, you know, why do we put fluoride in drinking water?
Why is there fluoride in toothpaste? Why did dentists use fluoride? And why are we using chemical antiseptics as a mouth rinse every day? So you have to go back more than a hundred years, right? And it was first realized this oral systemic link, people with poor oral hygiene had a higher incidence of heart attack, stroke, and I think all cause mortality.
So then it was like, and then they started isolating oral pathogenic bacteria in the thrombus of people who died from sudden cardiac death from a heart attack. And so it was okay that there's bacteria in the mouth, bleeding gums, those bacteria trains, okay? Causes systemic inflammation. Plaque ruptures, heart attack, stroke, and people die.
So the strategy a hundred years ago, well, let's kill all the bacteria, right? Let's use antiseptics. But now, fast forward, we know that there's a microbiome present in our mouth, in our gut, on our skin, and these bacteria that live on the human body, in the human body outnumber human cells tend to one. And now we know that we have to support the microbiome.
We can't kill it. But yet, in dental medicine. In public health, we're still putting antiseptics in drinking water. 73% of municipalities in the US put fluoride in their drinking water. Most toothpaste have fluoride in them, and then two outta three Americans use antiseptic mouthwash every day, and the consequences are very clear and they're indisputable.
You use mouthwash, your blood pressure goes up, your blood pressure goes up because you're killing nitric oxide producing bacteria. Hypertension is the number one driver of the number one killer of men and women worldwide, which is cardiovascular disease. Mm-hmm. Then fluoride fluoride's, not only an antiseptic, it's a, it kill shuts down your thyroid and it's a neurotoxin.
So this is where it all begins. And mechanistically, we understand this and so we've, we've gotta get rid of fluoride. You gotta get rid of fluoride in your toothpaste. You gotta stop using mouthwash and then start doing things that promote and support the ecology of a healthy microbiome. And then the good guys will keep the bad guys
Dr. Brandon Crawford: at bay.
Absolutely. Well, I think one concept to kind of think through, I think the majority of people listening would agree that, Hey, if I told you you need to wipe out all the bacteria in your gut, do you think that's a good idea? I think everyone would collectively say, absolutely not. That's terrible. Well, this is the same concept.
We need this fluoro. We need this microbiome, like you said, everywhere. It's all over us. It's inside of us. You developed a toothpaste and I actually use it. My kids use it. Can you tell me what, like why'd you develop a toothpaste and what's so special about it?
Dr. Nathan Bryan: You know, as a nitric oxide biochemist, I'm interested in, in number one, understanding how the human body makes nitric oxide, what leads to a loss of its natural production.
And then how do we develop lifestyle strategies or product technology that can prevent this loss of nitric oxide production? So we knew about the damages and effects of fluoride, and I've been using a fluoride free toothpaste for probably more than 20 years. But when I look at these products, there were still things in there, detergents chemicals that really, we had data that were destroying the oral microbiome.
So there really wasn't a product that needed to do what it, what I needed it to do for my own oral Fluor and for everybody's oral fluoride. So I was forced to develop a a, a nitric oxide, microbiome friendly toothpaste, number one. Obviously it's fluoride free. It's a hydroxy appetite based product to help remineralize the teeth, but we put things in there that are selectively killing pathogenic bacteria.
But also act as prebiotics to help restore the normal flora, improve the diversity of the oral microbiome, and improve nitric oxide production. And what we're finding is that people who switch to our toothpaste that have what's called resistant hypertension, their blood pressure starts to come down.
'cause now we're not destroying the microbiome. We're improving the microbiome. Their nitric oxide production improves and their blood pressure improves. And in fact, I'll tell you a funny story. I was went to my dentist for the first time in three years last week. For a cleaning, and I go in and they, they, they go, Nathan, it looks like we just cleaned your teeth yesterday and it's been three years almost to the date since you've been in here.
They go, what are you doing? You have no tartar buildup. Your bacteria load is a one, which is the best on their scale, and your teeth are, are incredible. They go, well, it's, it's, it's what I do and the dentist obviously that I go to know that my toothpaste and kinda my oral hygienic practices. You know, exposed to this, this field of dialog, biological dentistry.
So, and my entire family, my wife, my kids, everybody who's using this has incredible dental visits. When they go and they go, whatever you're doing, keep doing, because we've never seen your dental hygiene as good as it is now.
Dr. Brandon Crawford: That's awesome. Yeah. Actually, the person that introduced me to your toothpaste was my biological dentist doctor.
Joan ick. Oh yeah. She was, you know, she's a avid promoter and she, you know, loves your products and she literally just goes, here, use this. And I'm like, what is this? She's like, just, just use it. I was like, we're friends though. So, you know, that's, that's our relationship. And I was like, okay, I'll figure it out on my own.
And so, but that's good. 'cause then I went and I read about it and I said, oh wait, this really makes. A lot of sense because my first connection point was, what does nitric oxide have anything to do with toothpaste? Why I don't understand this? Is this a marketing gimmick? Right? And but she was like, Nope.
Go read about it. Educate yourself. Here you go. I gotta go. And she leaves. And so as I started look, looking into it, I'm like, holy smokes, this makes so much sense. And so, like I said, you know, we all use it. I definitely think everyone should, should use it. Since we're on that topic, let's, let's kind of talk through a little bit about this concept of mouth breathing, nose breathing.
How does that impact nitric oxide levels and ultimately our health status? Right? This is a big topic.
Dr. Nathan Bryan: Absolutely. Now, mouth breathing is probably one of the worst things you can do for your health. So I'll tackle this from both sides. So, nasal breathing, you know, the enzyme nitric oxide synthase. Enos is also is found in our endothelial cells, is also found in our epithelial cells, our upper airways.
And so when we do nasal breathing, that activates this enzyme that produce nitric oxide. And then we deliver nitric oxide gas to the, to the pulmonary arteries. We dilate the pulmonary arteries, we dilate the bronchials, and we improve tissue oxygenation in in blood oxygen saturation. That's why deep breathing, nasal breathing can lower blood pressure.
It's a nitric oxide related effect. Also, an autonomic nervous system response. So if your mouth breathing, not only are you bypassing this nitric oxide production pathway through the sinuses, but you're completely disrupting the oral flora in the microbiome. The mouth is not a breathing instrument, so the mouth is designed to be closed except when speaking.
And so when you're breathing through your mouth, you're fully oxygenated, you're changing the pH of the saliva. You're changing the entire communities of, of the microbiome to a more acid loving caries causing gingival periodontal disease communities, and less of these non-pathogenic commensal bacteria.
So mouth breathing diverts or ti sidesteps the nitric oxide production through the nasal sinuses, and it completely inhibits the nitric oxide production from the oral flora in the mouth. So it's the worst thing you can do, and I think the data. Very clearly you know, long-term outcome studies in mouth breathers are, it's, it's horrible.
We've gotta do mouth taping, but, you know, I tell people before you tape your mouth, you need to go see an airway specialist and make sure you don't have an anatomical obstruction that you can actually breathe if you do mouth, mouth taping.
Dr. Brandon Crawford: Yeah. Actually mouth taping used to really freak me out.
Right. And the whole concept of why in the world would you. Suffocate yourself just to breathe through your nose. Like I, I was like, this is crazy. Why are people doing this? And then I read the book breath or Breathe, I forget, by James Nestor. Yeah. Which by the way, is a phenomenal read. I've actually, I'm on my second round of reading it, so I, I read through it quickly the first time and I actually got to meet him.
And have some cool conversation with him. And I thought, you know what, I'm gonna go back and really read this book. He does a phenomenal job of outlining the full history of, you know, skull Development, brain development, why? Nasal breathing, mouth breath, breathing matters. And, you know, even didn't experiment on himself where they clo, you know, him and another guy closed their nose, only breathe through their mouth, measured the metrics.
I mean, it was huge. It was very far reaching about how this really has an impact on overall health and longevity and inflammatory status and all kinds of things. It was very eye-opening and so, but you're right. Don't just go out and start taping your mouth. Let's work with someone you know, qualified and can evaluate, advise accordingly, et cetera.
Very good, very good.
Dr. Nathan Bryan: Yeah, no, it's eye opening. You know, I see kids now when I'm flying, or, or going through airports, little kids, you know, even infants and, and toddlers, you know, sleeping with their mouth open. I mean, and that's the, I almost wanna say something to the parents, because to me that's an obvious sign and symptom that.
They need some corrective action now, because if those kids are mouth breathing at that age, you know, they've got a long road ahead of them. Absolutely.
Dr. Brandon Crawford: I just wanna reach over and close your mouth. Right, like, here, let me close your kid's mouth for you. Let me put some tape on it. I'm sure no one would care about that.
And so we, you've talked about blood pressure quite a bit, so let's kind of go into that a little bit. 'Cause a lot of docs, right, just your traditional medical providers, they're gonna prescribe. Some type of medication, you know, ACE inhibitor or something like this. Why, first of all, isn't that frustrating to know that they don't really understand the mechanism of action about what's really going on here, but help break that down, why that's maybe not such a good idea?
Dr. Nathan Bryan: Well, physicians I think, are well intended, right? And they have to practice within what's called the standard of care, right? And it's clear the standard of care is not making anybody better. But, you know, nitric oxide really addresses the physics of hypertension. And so let's think about this. We go back to, to our basic, you know, high school physics pressure equals volumes, times resistance.
Peak equals vr, right? So we've got a finite volume of blood pumping through our body every second. And so if we make nitric oxide, now we can dilate these blood vessels and decrease the resistance. Because now we've got the same volume of blood going through bigger pipes. So pressure comes down. Now, if we lose the ability to produce nitric oxide, the vessels become constricted.
Now we've got that same volume of blood going through smaller pipes, and that equation tells us the pressure has to increase. So if we give nitric oxide, we dilate the blood vessels, we bring pressure down, we normalize blood pressure. Now, most physicians, if you have high blood pressure, they'll put you on, as you called it, an ACE inhibitor.
Which is an angiotensin converting enzyme inhibitor. Or they'll put you on angiotensin receptor blocker, or they'll give you a calcium channel blocker or they'll give you a diuretic, or the worst physicians will put you on a beta blocker to pace your heart to where you can't maintain optimal pressure.
Voice Over: Right.
Dr. Nathan Bryan: But we know from the clinical data that 50% of the people that are given these medications don't respond with better blood pressure. And to me that's, that's as clear as day. But most people don't see this. 'cause the reason they have high blood pressure is not due to ran angiotensin issue. So ACE inhibitors, ARBs aren't gonna lower your blood pressure.
It's not due to dysregulation of calcium. So calcium channel blockers aren't gonna decrease your blood pressure. And it's not due. I mean, some cases it could be a volume overload. So diuretics will bring your pressure down just because it's it's depleting volume. So if we just start addressing. What's causing a loss of nitric oxide production?
And you start asking, these patients have high blood pressure. Are you using fluoride in your toothpaste? Are you, is, does your toothpaste have fluoride? Do you use mouthwash? And when you start querying your patients now, and they say, most people say yes to the fluoride toothpaste, two outta three Americans use mouthwash.
They go, okay, switch to a fluoride free toothpaste. Stop using mouthwash. Come back in 30 days. Let's measure your blood pressure. Remarkably, in most all cases, their blood pressure becomes more normal and it decreases. So then we can start to interrogate these different systems and, and addit and, and provide additional support for nitric oxide.
And you can normalize blood pressure. You can get people off prescription medication. That should be the goal of medicine. That should be the goal of every physician to make the patient better to where they're no longer on prescription medication.
Dr. Brandon Crawford: Absolutely. So if you're normalizing blood pressure. Would you also in turn be improving heart rate variability and other metrics like this?
Dr. Nathan Bryan: Absolutely. Now we've done HRV measurements getting improving people's nitric oxide production. HRV improves. We're seeing an increase in, in the circulating number of stem cells. We see the telomeres activated. We see no. Telomeres get longer, we see mitochondrial biogenesis. And so everything improves this by improving the production of the single molecule, nitric oxide.
Everything else seems to get better.
Dr. Brandon Crawford: So stem cells, so you're saying that improved nitric oxide levels, mobilizes stem cells. Does it also help with differentiation or any other component of that stem cell story?
Dr. Nathan Bryan: Well, in 2006, there was a Nature Medicine paper published showing that nitric oxide is the signal that tells our own stem cells to mobilize and differentiate.
So in patients who can't make nitric oxide, their mo, their, their stem cells, whether it's in bone marrow or adipose, or any type of tissue, the the stem cells never get the signal. To mobilize. Mm-hmm. Now there's different stages of differentiation in the different cell types where nitric oxide plays a critical role.
And we published a paper with, with Fred Mirad when I was, he was, when I was at the Institute of Molecular Medicine, where we could induce stem cells into mitochondrial beating my myocytes cardiac myocytes by giving nitric oxide donors in certain stages of differentiation. So then in, in, in neural cells, there's certain stages of differentiation where you can direct those into di differentiation.
So we don't clearly understand at what stage we can direct this, but certainly in mobilization, nitric oxide plays a critical role. And in our paper, we could specifically induce embryonic stem cells into beating cardiac monocytes by giving nitric oxide at certain stages.
Dr. Brandon Crawford: That's quite amazing. We do some regenerative medicine procedures here and one of them involves V cells, very small eem like stem cells, and we like to do everything we can to increase the number of V cells and mobilize stem cells.
Prior to, prior to the procedure. And so using light is a huge component, right? Mm-hmm. So we're having the person go through the arc bed or using very specific laser therapy over long bones and you know, these areas to increase the mobilization of those cells. Know, I've never actually considered like we should use your product, the N 1 0 1 product.
So what would be the best timing in these scenarios? Like an hour before we're harvesting, like the day before. I mean, obviously we want to optimize as soon as possible, but I mean, if I wanna really get a peak efficiency is there, could I do this the morning of and then harvest? I mean, what, what do you think?
Dr. Nathan Bryan: You could, yeah, certainly the, the, the morning of. But I'll, I'll tell you what we, what we know and then I'll tell you what we think. We know that if you can get this product into patients at least 30 days before the procedure, then we, we start to see, we can quantify the amount of circulating stem cells.
And we've published on this in a pediatric patient with a rare genetic disorder at Texas Children's Hospital. I think as long as you can get it in them, you know, 30 days would be ideal. One lozenge twice a day. But the morning of, you know, we, we've got a number of regenerative medicine clinics, stem cell clinics who deploy stem cells, whether it's, you know, autologous stem cells or allogeneic cells or exosomes or whatever type of product they're using.
But they always give our nitric oxide lozenge prior to the deployment of stem cells or to try to mobilize it, whether it's light therapy. But yeah, you can do it because this lozenge is so quick acting, you can do it. Like, for instance, for IV deployment of stem cells, we put the lozenge in our mouth.
We start an iv, we open up the microcirculation. Now you're gonna get a more efficient delivery of those stem cells you're trying to deploy. Or if you're using light therapy as a, as a strategy, put the lozenge in. You know, five minutes later, 10 minutes later, you know, hit 'em with a light. That's
Dr. Brandon Crawford: awesome.
Yeah. Well, I'm gonna be ordering a, a ton more of those 'cause we're just gonna be folding 'em into the into the procedure, so that's great. Tell me a little bit more about the lozenge and, and the product and how does it work?
Dr. Nathan Bryan: So this was based on a number of discoveries I made when I was still in academia because my objective when I was in academia was to understand how the human body makes nitric oxide.
We understand the enzymology and the biochemistry. We certainly understand the oral microbiome. And then once we understood what led to a loss of this production, what leads to NOS coupling, what leads to oral dysbiosis, then I started developing product technology. How do we restore the function of the NOS enzyme?
And the whole process was based on our 2007 paper we published in the Proceedings of National Academy of Science, showing for the first time that nitric oxide is a hormone. So when you start to look at nitric oxide as a hormone, we can start to employ what's called hormone replacement therapy. Right?
And it's not dissimilar to testosterone, right? If men are low in testosterone, we give them testosterone. We don't give them pregnant alone. We don't give them DHEA and close our is and cross our fingers and hope their body can make testosterone. We give them the molecule, and that's the same thing we do with nitric oxide.
And it was a little bit frustrating for me because there were all these companies out there selling arginine, citruline, beets and all that, trying to as a nitric oxide product, but understanding that these products can't work because they don't address the underlying issue. So I started making an orally disintegrating tablet.
So number one, if your body can make nitric oxide, then we gotta do it for you. So the lozenge is designed, I designed it to have a certain resident time in the mouth, five to six minutes. And as it's dissolving, we're releasing a certain amount of therapeutic amounts of nitric oxide. It's absorbed oli, it dilates blood vessels within 12 seconds in the carotids.
And we can now understand the other thing. Going back 20 years ago, we had to understand when nitric oxides produced, where does it go? What does it become? And what's the half-life of all these second messenger systems? So everything we do in terms of drug therapy, product development, I wanna recapitulate physiology.
I wanna mimic the natural production. Nitric oxide and so that, that the nitric oxide lozenge was born. And so again, you put it in your mouth, you let it dissolve, it releases nitric oxide, and we activate these second messenger systems that recapitulates what it would, what would happen if your body's naturally producing it.
And because it sits in the mouth, we're, we're selectively killing the pathogenic bacteria. We're providing nitrogen as a substrate for these nitrate reducing bacteria. That's as a prebiotic. And then we've recouped the nitric oxide synthase enzyme in the lining of the blood vessel, and we have data showing that if one lozenge within 20 minutes have taken it, we've improved endothelial function by on average about 20%.
In some patients with really poor endothelial function, we see a 65% improvement within 20 minutes of taking a single lozenge. So if your body can't make it, we do it for you, but we fix the reason your body's unable to make it.
Dr. Brandon Crawford: Is there a negative feedback like there is like with taking testosterone where you then become dependent upon this?
Dr. Nathan Bryan: No, and in fact, I, I tested that y probably two decades ago when I first had this concept of developing a product because I didn't want there to be feedback inhibition as a for-profit company. It's a great financial model because now people become dependent on your product. Right? But as a biochemist and physiologist, I want to address root cause.
So there isn't the feedback inhibition where we see an, if we give exogenous nitric oxide, we don't see an inhibition of the endogenous production. Okay. In fact, just what I mentioned, if we look at FMD or flow media dilatation, we show that we're actually improving the body's ability to na to naturally produce it.
So we see that the, the exact opposite of tolerance for tachyphylaxis, we've see an improvement in the natural production.
Dr. Brandon Crawford: That was my question is do we actually develop some plasticity to where we're actually starting to upregulate these systems is so you just answered that. So what about contraindications are, is there someone that should not take this product?
I.
Dr. Nathan Bryan: You know, I say there's only two people in the world who need nitric oxide. It's people who are sick and want to get well, and it's people who are well and don't want to get sick. Now when taken as instructed, but you know, dose dictates poison. There's every molecule is, is toxic, depending upon the dose.
Dr. Brandon Crawford: Mm-hmm.
Dr. Nathan Bryan: You know, so what we have to do and co what we call our CYA statements with the FDA is if there's a biologically plausible mechanism where there could be an interaction. Between nitric oxide and some drug therapies or classes of drugs, then we have to reveal that and we put that on the label.
So number one, we say if you're taking a PD five inhibitor, that there could biologically plausible mechanism whereby nitric oxide could increase cyclic GMP, the PD five inhibitors would lead to an unsafe drop in blood pressure. So it's biologically plausible. Do we see it? No. The other is in anti-platelet medication.
And really the only thing we worry about is warfarin and Coumadin. Okay? Because those, those drugs are hard to manage. INR levels, you have to constantly monitor, you know, dietary changes. Vitamin K exposure will, will affect bleed times. But I, I can constantly tell you that the lozenge itself does not affect platelet activity, does not extend bleed times.
But the combination of an anti-platelet therapy with nitric ide, 'cause nitric ide, if you look at the literature. Certain doses can inhibit platelet aggregation. If the doses we're delivering in our products, it will not affect platelet function.
Voice Over: Okay?
Dr. Nathan Bryan: But those are the only two kind of biologically plausible mechanism.
We've done drug studies in hundreds, maybe thousands of patients now, and some of these patients are on 18, 20 different medications. We haven't seen any safety signal in any of our drug studies, even in patients on 18 to 20 different medications. So we feel very good about the safety profile of not just our consumer products, but the drug therapy we're developing through the FDA.
Dr. Brandon Crawford: So there's a, there's a patient demographic and it's, it's my seizure patients, right? So seizure patients are typically. Very sensitive to anything you give. Right? So they're gonna be the demographic that typically will tell you if something is too much or too little or, or whatever, right? They're typically challenging, whether it's supplementation or drugs or whatever.
Do you have a demographic or case reports of people with seizures reacting favorably to this?
Dr. Nathan Bryan: No, we don't. You know, we've never done any randomized controlled studies. In fact, I don't even think we have anecdotal data. In seizure patients we typically try to stay away from those high risk
Voice Over: mm-hmm.
Dr. Nathan Bryan: You know, kind of complicated patients we're, we're focused more on affecting kind of vascular metabolic function of age-related disease and Right. Trying to make people live a longer, healthier, better life free of disease. Sure. But, you know, I think in seizures, obviously it's a, there's a, there's a problem in both an electrical activity, the electrical activity of the cell and the brain.
There's probably a vascular component. There's a vascular component too. Every disease. But, you know, I always say if we, if we can better perfuse organs, tissues, and cells and better deliver oxygen and nutrients, then those cells have to perform better and they will function better. And that's what nitric oxide does.
Dr. Brandon Crawford: Absolutely. So plausibility of you know, using the using your lozenges in someone with a seizure, right. It makes sense to where this could help with someone with seizure. Right. So, I as a clinician can explore that and, and I can report back. But we'll definitely be doing some of that work.
I'll let you know how it goes. I, I think it'll be very good.
Dr. Nathan Bryan: Look, and that's what we rely on. We, we rely on physicians to use their best medical judgment for that particular patient. And I think that's. What allows, you know, that's what makes good physicians and clinicians is using the preponderance of the evidence and their best medical judgment, what's best for that patient, whether it falls within the standard of care or not, you have to do what's best for that patient.
Dr. Brandon Crawford: Right. Well, what I can tell you is that so many of these patients do have abnormal oral microbiomes. Yeah. And abnormal GI microbiomes. So I mean, the connection, the connection is there. It just makes sense to continue to connect those dots. Going back to your discussion on contraindications, you brought up PD five inhibitors.
So this would be Cialis, Viagra, this type of stuff, or erectile dysfunction. And from what I am understanding, you're calling that more of a relative contraindication, not an absolute contraindication. But if I understand correctly, based on what you're, you were describing earlier, this could actually replace the PDE five inhibitor, right?
That's right.
Dr. Nathan Bryan: Yeah. Most people think, and even a lot of physicians think that the, the viagras of the world are nitric oxide donor drugs, and they're not. They're dependent upon nitric oxide production, but they act downstream of nitric oxide. So the signaling cascade goes as this nitric oxides produced, it diffuses in the underlying smooth muscle binds to an enzyme called GU cyclase.
That enzyme converts GTP into cyclic GMP and then cyclic GMP mobilizes, calcium smooth muscle relaxation, vasodilation. And the PD five inhibitors come in 'cause they prevent the breakdown of cyclic GMP, right? So they potentiate the effects of nitric oxide signaling and potentiate vasodilation. But we know these drugs have been on the market since 1998 and 50% of the men that are prescribed these drugs do not respond with better erections.
And so these drugs, billion dollars a year, but they only work in one outta two people. And the reason the non-responders are non-responder is because their body's not making enough nitric oxide. To activate Guan cyclase, so there's no increase in cyclic GMP. Mm-hmm. So we have clinical data. We can take non-responders to PD five inhibition therapy, give them our lozenge, activate guan cyclase, increase cyclic GMP.
Now the PD five inhibitors actually work and the men get better erections. And so once, once you understand that mechanism and that signaling cascade, you can titrate down the dose of the drug so you can mitigate the side effects, you can improve the erectile response. And then if we just improve nitric oxide production, then we, there's no need for PD five inhibition therapy because that signaling cascade is intact.
Now, you can amplify the effect by giving low dose like the five milligram once daily. Cialis, I think is a, is a pretty good drug because there's data showing that people who've been once daily Cialis have lower incidence of Alzheimer's. They're protected from COVID. They get better erections, better performance, better pulmonary perfusion that lowers pulmonary pressures and pulmonary hypertension.
So these aren't bad drugs if you understand their mechanism, how they're working and how you can improve their efficiency and efficacy. Right?
Dr. Brandon Crawford: Yeah. There's actually literature looking at small doses of Cialis even for brain injury. I mean, it, it, it makes sense, right? All about profusion. Yeah, absolutely.
You gotta have blood flow everywhere. Without it, you not gonna work for sure. So I know that testosterone propagates. Nitric oxide production. And I've definitely experienced that, right? I've had to really work hard to get my testosterone levels up when they come up. You know, right now they're in the 800 ish range, right.
I feel better than I have, you know, since I was 18. Yeah. But I have better blood flow and it was amazing. You know, my, my kid even noticed like, he touched my hand. He goes, dad, your hands are warm. My hands were always cold. Right. But I'm curious, can it work the opposite direction? Can you improve your nitric oxide and thus improve your hormonal systems?
Does it work both ways?
Dr. Nathan Bryan: It can, and it should, but it doesn't always do that. Right? Because there's certain things that are disrupting natural testicular testosterone production, right? There's these things that we're exposed to, whether it's, you know, environmental toxicants, whether it's, plastics and things like that.
So it's disrupting the normal secretion of testosterone. But here's what we, here's what we know, that testosterone is a na natural activator and stimulator of nitric oxide production. So in, in, in men who are in it, women too, going through hormone replacement therapy with, with estrogen, estrogen has a positive effect on stimulation of nitric oxide production.
But we ha that that enzyme has to be coupled and functional. So what I encourage people and endocrinologists in hormone clinics. To give people our lozenge to recouple the nitric oxide synthase enzyme. So now when you replace the testosterone and, and optimize estrogen and hormones in both men and women, you can induce that cardioprotective benefits of hormone replacement therapy.
Because it's activating nitric oxide production, the enzyme is coupled and functional, and you can activate it if you don't. If you still have endothelial dysfunction and you're giving testosterone or estrogen your testosterone's elevated. But you lose the the protective benefits of a hormone replacement therapy, and that means that typically just by improving your testosterone levels doesn't always translate into better erections and better erectile function to focus on recoupling the NOS enzyme so that you can get activation of nitric oxide and vasodilation, better erections, better performance, not just sexual performance, but cognitive performance and physical performance.
Dr. Brandon Crawford: Yeah, I mean it's, it's amazing how, you know, we can go in all these different directions by talking about nitric oxide. I mean, I love that we, you know, initially touched on Alzheimer's and we went into mitochondria, and then we went into the microbiome and it, I mean, it's a foundational molecule. It's a foundational,
Dr. Nathan Bryan: it's not a pan,
Dr. Brandon Crawford: but it, it's foundational.
It's quite amazing. So. Why in the world? Like why are we not, when, when I say we, why, why is our medical system, our universities doing a lot of research, pharmaceutical companies doing research? Why is the focus not so heavily on nitric oxide? If. We already know these connections exist. We already know this is a central molecule to health and longevity.
Why are we not? I know you are and I'm thankful for that, but why is this not a common theme in medical literature?
Dr. Nathan Bryan: Well, 30 years ago it was, in fact, when I started in this field, most major pharmaceutical companies, big pharma, had a nitric oxide drug development program. But they were, they were chasing the wrong target and what their, their approach was to take.
And we, we did this, we had a contract with with Merck when I was at Boston, and we created a Nitro Eter link to a Cox two inhibitor, a selective Cox two inhibitor, the Vioxx, the Celebrex, to try to mitigate the cardiovascular side effects of these selective Cox two inhibitors. Then there was a company called Oxx outta France, who was making an N no aspirin.
Aspirin with a nitro eter bond linking a Niro IDE molecule. And the, the preclinical data look good, but the, the clinical trials similar to nitroglycerin and organic nitrates, patients develop tolerance to this because it requires that same type of metabolic activation. So when ni, I mean, the company spent hundreds of millions, perhaps billions of dollars on these modified parent drugs in a modified drugs.
And the FDA didn't approve it. I think they voted it's like 16 to one, not to approve it on safety, not even efficacy. It was a safety issue. So then I think every, every pharmaceutical company abandoned that pipeline. And then we came along and my patents, my discovery. So I made a solid dose form of nitric oxide gas.
So we produce nitric oxide, and it's not a, it's not a synthetic compound that I manufactured. It's basically a way to replete and reproduce nitric oxide production. So we're develop, we've been very successful in the nutrition dietary supplement space, but we're developing this now as drug therapy.
We've got a drug that we're about to, I phase three for. Ischemic heart disease where, you know, we've met with the FDAA pre IND meeting with, for our Alzheimer's drug. We're developing a topical drug for diabetic ulcers. So there are other companies out there developing this, but, you know, we're so far ahead of where anybody else is and, you know, I think it's gonna change the landscape of medicine when we get our drugs approved and on the market and it's gonna, it's gonna change people's lives.
We already see it in the, in the nutrition and supplement industry. But, you know, my goal is to give the physicians. Safe and effective drug that they can prescribe is covered by insurance that actually makes their patients better instead of putting them on additional pharmaceutical agents and, and synthetic compounds and inhibit biochemical reactions and making them sicker.
Dr. Brandon Crawford: Right. That's an amazing mission. I wish that more people doing similar work but actually share that mission, but that's amazing.
Dr. Nathan Bryan: So Well, it's disruptive and, and it's not very well accepted in the industry because when you think about what we're doing and what we're gonna do is when we, we develop our nitric oxide product portfolio in nutrition, in skincare, in oral care.
In drug therapy, people will come off medications. And when you start to impede upon the market share of big pharma, this is not well accepted. My goal is to, from day one, was to understand the mechanism of disease so we can develop rational therapies and get people better, get people off of drug therapy.
That should be the goal of medicine, but it's not the goal of a big pharma. These are for-profit companies participating in a multi-trillion dollar global
Dr. Brandon Crawford: business. Right. And obviously that comes with a lot of pushback. Have you already started to see some of that pushback or are we early days still?
Dr. Nathan Bryan: Oh no.
Look, I've, I've been, I've been ridiculed, I've been opposed. People sue me, companies sue me. No, it's, it's, it's a vicious world out there. But, you know, I stand on our science and I stand on our product technology and, you know, the science leads the way I'm, I'm less interested in, you know, you know, selling products as I am, is advancing the science and, and getting our products approved and, and, and, you know, counting all these naysayers and, and, and shutting them up and leading the way.
Because, you know, they can try to shut me down. They can try to silence me, they can sue me, cost me millions of dollars. But you know, we're still in the fight and we'll continue to be in the fight and we're leading the way.
Dr. Brandon Crawford: Yeah. Well, I know, I'm definitely thankful for all the things that you're doing, and I hope everyone can really dig into your passion that, you know, you just elaborated on, you're doing this for the right reasons, and you're willing to fight the fight.
I think that's one thing, right? I mean. I don't think I've fought the same type of fights that you've been fighting, but I've even had to fight, you know, to, to help do the things that we are doing. And that can be at the government level, that can be in the, the private entity level, whether it's a competitor, whether it's, I mean, there's so many different things that can come against you.
I'm just very thankful that you're willing to engage in those push forward for a better world, a better society for me, for my kids, for my patients, for all these people that are willing to listen, right? Thank you so much for doing that. What I do want, thank you, Brandon, people to understand is because I know everyone's gonna wanna try these products.
What, where can they find them? Where, where can they get the these amazing products?
Dr. Nathan Bryan: Well, first I encourage people just to get educated. I mean, this is a great conversation and that's the power of these podcasts. 'cause you know, most people have ever heard of nitric oxide and when they start to con consider how important it is, then they can, you know, take these steps to improve their own production.
Our products can be founded. N one oh one.com. That's the letter n number one, letter O number one.com. But you know, for me it's about education and awareness of, you know, send people to my YouTube channel, Dr. Nathan s Brian, nitric oxide, I've. Book that I launched about five months ago called The Secret of Nitric Oxide.
Bring The Science to Life. It's a great read. It talks about the story of nitric oxide, kinda my own personal journey of discovery and, and product innovation. And then I'm on social media, Instagram, Dr. Nathan s Brian, LinkedIn. I'm searchable.
Dr. Brandon Crawford: Yes, absolutely. Well, is there anything else you want to tell the world about your mission or nitric oxide or anything before we sign off today?
I.
Dr. Nathan Bryan: No, I, you know, I just encourage people to get educated you know, understand the science of it. And, you know, there are a lot of companies out there selling so-called nitric oxide products and, you know, don't get caught up in the fraudulent marketing because, you know, beats aren't nitric oxide. Yes.
And beats are probably the, the worst way to try to deliver nitric oxide out there. And yet, you know, companies are spending millions of dollars every week on TV advertising, trying to sell you beats as a source of nitric oxide. So. You know, just understand the science and you know, so you can make educated, informed decisions and not waste your money on products that not only don't work, they can't work.
Dr. Brandon Crawford: Absolutely. Well, sir, it is been a pleasure. I would love to pick your brain for another couple of hours, but I know you've got a world to save and things to do. So thank you again for your time. Thank you again for your mission and your passion. Everyone out there, please look into Dr. Nathan Bryan and everything that he's doing.
We are so thankful for his work. Nathan, thank you so much.
Dr. Nathan Bryan: Thank you, Brandon, for being with you.
Voice Over: We hope today's episode has inspired you to take that next step towards your best self. Remember, the path to longevity is paved with small daily decisions. Your journey is unique and every step, every choice brings you closer to your ultimate vision of a healthier, happier life. For more insights, tips, and resources, visit drbrandoncrawford.com.
